Translational Endocrinology of Bone by Gerard Karsenty

By Gerard Karsenty

The use of version organisms including the facility of genetics has profoundly affected our realizing of the body structure of 1 organ, the skeleton, in distinctive yet complementary methods. This is the 1st translational connection with specialize in those significant conceptual advances in bone biology and their improvement within the health facility. numerous advances have already been translated into cures and others are being proven for illnesses as diversified as osteoporosis, type-2 diabetes, and hypo-fertility. This publication is a well timed reference for either easy and scientific researchers in bone biology and endocrinology.

  • Summarizes the newest learn and translational purposes of the way the numerous progress and improvement of bone impacts urge for food, metabolism, replica, and quite a lot of endocrine services
  • Provides a typical language for bone biologists, endocrinologists, osteologists, and different researchers, equivalent to neuroscientists, who learn urge for food, gas metabolism and diabetes, to debate the advance of translational learn and new healing ideas for bone, metabolic, and neuro-endocrine diseases.
  • Saves researchers and clinicians time in speedy getting access to the very most modern information on a huge variety of bone learn and therapeutics, in place of looking through hundreds of thousands of magazine articles

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Local Actions of NPY on Osteoblast Activity In addition to skeletal changes following alterations in hypothalamic NPY expression, there are non-central actions of the NPY system that alter skeletal homeostasis. NPY knockout mice display elevated osteoblast activity; however, reintroduction of NPY into the hypothalamus OTHER NPY LIGANDS of these mice is not sufficient to completely normalize osteoblast function, suggesting the existence of noncentral actions in NPY to regulate bone mass [36]. Indeed, NPY has direct effects upon osteoblast activity.

THE NPY RECEPTORS Y1 Receptor The Y1 receptor, so named because it was the first to be successfully cloned [47], consists of 384 amino acids and binds the NPY family of ligands with the following order of potency: NPY ¼ PYY >> PP [47,48]. Y1 receptor expression, ascribed using mRNA and/or protein detection, was detected in the hypothalamus and hippocampus, several thalamic and amygdaloid nuclei of the rat and mouse [49,50]. In the hypothalamus of humans, as in rodents, Y1 receptor mRNA was detected in the arcuate and paraventricular nuclei [51].

Bray GA, York DA. The MONA LISA hypothesis in the time of leptin. Recent Prog Horm Res 1998;53:95e117. Satoh N, Ogawa Y, Katsuura G, Numata Y, Tsuji T, Hayase M, et al. Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes 1999;48(9):1787e93. Kurvers HA. Reflex sympathetic dystrophy: facts and hypotheses. Vasc Med 1998;3(3):207e14. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART.

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