The Skin in Systemic Autoimmune Diseases, Volume 5 (Handbook by Piercarlo Sarzi-Puttini, Andrea Doria, Annegret Kuhn,

By Piercarlo Sarzi-Puttini, Andrea Doria, Annegret Kuhn, Giampietro Girolomoni, Ronald Asherson

This e-book represents the state of the art within the box of dermis and autoimmune rheumatic ailments. It covers systematically a starting to be and multifaceted subject that is of significant value within the scientific perform. It additionally serves as a pointy academic device as every one bankruptcy presents summaries and particular highlights to key references brought up into the textual content. The pathophysiological hyperlink among epidermis involvement and autoimmunity has been defined intimately, in addition to diagnostic and healing aspects.This e-book yields a powerful physique of good ordered details which summarizes the event of a chosen panel of distinctive physicians and scientists actively focused on the sphere of dermis immunology and systemic autoimmunity. * Written by means of a revered panel of unique physician-scientists actively all in favour of the sphere of pores and skin immunology and systemic autoimmunity* field summaries on the finish of every bankruptcy spotlight very important issues * updated uncomplicated wisdom in addition to sleek method of prognosis and remedy

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2001. The immune dysregulation, polyendocrinopathy, enteropathy, Xlinked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20. , Mathis, D. 2001. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?. Nat. Immunol. 2, 797. , et al. 2005. Cutaneous Tcell lymphoma: malignant proliferation of T-regulatory cells. Blood 105, 1640. , et al. 1997. Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes. FEBS Lett. 417, 301.

Coincubation of Treg and effector T cells results in the downregulation of IL-2 expression in the latter. , 2002). , 2004). Some of these molecules have been shown to be important for the suppressor function of Treg. , 2003). Foxp3 is highly expressed in CD4+CD25+ T cells in humans and rodents. In mice, deletion of Foxp3 results in loss of Treg and development of severe lymphoproliferation. , 2001). , 2005). Using a Foxp3-specific antibody, Foxp3+ cells can be detected in situ in the T cell area of human lymph node tissue demonstrating their distribution pattern (Fig.

182, 58. , et al. 2002. CD4(+) and CD8(+) anergic T cells induced by interleukin10-treated human dendritic cells display antigen-specific suppressor activity. Blood 99, 2468. , et al. 1997. Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. 159, 4772. C. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 99, 351. , Gavalchin, J. 2000. Systemic lupus erythematosusmessages from experimental models. Rheumatology (Oxford) 39, 18.

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