The Power of Functional Resins in Organic Synthesis by Fernando Albericio, Judit Tulla-Puche

By Fernando Albericio, Judit Tulla-Puche

Whereas many books conceal good part synthesis and combinatorial synthesis, this one is exclusive in its specific insurance of the opposite features of solid-phase synthesis. As such, it comprises every little thing you must comprehend -- from supported reagents, to scavengers, resins, and the synthesis of biomolecules and usual products.
a useful significant other for all chemists and biochemists operating in collage learn and undefined.

Show description

Read or Download The Power of Functional Resins in Organic Synthesis PDF

Similar organic chemistry books

Biochemistry (6th Edition)

Become aware of how the most recent advancements in biotechnology, genomics, and proteins at once impact your lifestyles with Campbell/Farrell? s best-selling biochemistry textual content. identified for its logical association and applicable intensity of insurance, BIOCHEMISTRY, 6th variation, balances medical aspect with clarity that?

Organic reaction mechanisms

Offers the latest advancements in natural chemistry. Compiled by means of well-respected editors with a long time of proper event.

Microwaves in Organic Synthesis

The lengthy awaited re-creation of this entire two-volume reference has been thoroughly up-to-date and accelerated through 30% to incorporate chapters on ionic drinks, carbohydrate chemistry, multicomponent reactions, stable part peptide synthesis, carbon nanotubes and fullerenes. Written by way of the main eminent scientists of their respective fields, the chapters, which counterpoint each other, now additionally contain 8 new fields of software, resembling heterocyclic chemistry, cycloadditions and carbohydrate chemistry.

Additional info for The Power of Functional Resins in Organic Synthesis

Sample text

The polymerization is carried out in a sealed container. After completion of the polymerization, the container is broken and the polymer monolith is coarsely crushed, then ground and sieved to obtain particles of appropriate size range. The template molecules are extracted from the polymer. Finally, the polymer particles are dried. This protocol is time- and labor-intensive and produces large amounts of particles of unwanted size fractions. 5). 5 Scanning electron micrograph of irregular MIP particles.

The rebinding, however, relies on noncovalent interactions. When the covalently bound template moiety is cleaved from the MIP, a functional group capable of interacting non-covalently with the target molecule is left behind in the polymer at the cleavage site. The semi-covalent approach has been used successfully for the preparation of MIPs selective for p-aminophenylalanine ethyl ester [69], phenol [70] and triazines [71] among others. The cavity left behind after cleaving off the covalently bound template moiety is often too small to accommodate the target molecule during non-covalent rebinding.

Meldal, M. and Bock, K. (1999) Journal of the American Chemical Society, 121, 5459–66. 44 Atherton, E. C. (1989) Solid Phase Peptide Synthesis: A Practical Approach, IRL Press, Oxford. 45 Kempe, M. and Barany, G. (1996) Journal of the American Chemical Society, 118, 7083–93. 46 Meldal, M. (1992) Tetrahedron Letters, 33, 3077–80. 47 Renil, M. and Meldal, M. (1996) Tetrahedron Letters, 37, 6185–8. 48 Buchardt, J. and Meldal, M. (1998) Tetrahedron Letters, 38, 8695–8. , Meldal, M. and Bock, K. (1999) Chemistry – A European Journal, 5, 1088–95.

Download PDF sample

Rated 4.37 of 5 – based on 44 votes