The Nitro Group in Organic Synthesis by Noboru Ono

By Noboru Ono

The main worthwhile reactions of organonitro compounds in natural synthesis Compounds containing nitro teams are beneficial intermediates for the synthesis of normal items and different advanced natural molecules. The Nitro team in natural Synthesis specializes in reactions that continue lower than light stipulations, very important practical teams that may be synthesized by way of conversion of nitro teams, and the stereoselectivity of reactions of nitro compounds. those matters are of serious significance to working towards researchers in state-of-the-art pharmaceutical, agrochemical, and superb chemical industries. The Nitro crew in natural Synthesis additionally emphasizes environmentally-friendly equipment for nitration, the significance of aliphatic nitro compounds, and glossy instruction of nitro compounds. different issues mentioned comprise:

  • Henry reaction
  • Asymmetric Michael addition
  • Alkylation, acylation, halogenation, and comparable reactions of RNO2
  • Substitution and removal of NO2 and RNO2 The Nitro crew in natural Synthesis is an invaluable source for researchers and scholars in natural and medicinal chemistry.

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28 PREPARATION OF NITRO COMPOUNDS 86a. Reddy, M. V. , R. Kumareswaran, and Y. D. Vankar. , 36, 7149 (1995). 86b. , A. Gupta, S. V. Pitre, M. V. R. Reddy, R. Kumareswaran, and Y. D. Vankar. J. Org. , 64, 4509 (1999). 87. , and M. Hesse. Tetrahedron, 44, 1573 (1988). 88. Ballini, R. Synlett, 1009 (1999). 89a. , and C. Pslestini. Tetrahedron, 35, 5731 (1994). 89b. , and W. W. Zajac Jr. , 23, 135 (1982). 90. , and M. Petrini. , 16, 1781 (1986). 91. , M. Petrini, and V. Polzonetti. Synthesis, 335 (1992).

2-Nitro-1-propene: Preparation is accomplished by dehydration of 1-nitro-2propanol with methanesulfonyl chloride and triethylamine (30% yield),47 acetic anhydride-AcONa (85% yield),46 or phthalic anhydride (55%)45; bp 58 °C/35 mmHg (Eq. 25).

43b. Zang, M. , P. E. Eaton, and R. Gilardi. Angew. Chem. Int. Ed. , 39, 401 (2000). 44. , and D. Seebach. Chimia, 39, 356 (1985). 45. , J. Weiland, B. Undeutsch, H. Buchting, and R. Schon. Steroids, 62, 762 (1997). 46. Bull, J. , E. R. H. Jones, and G. D. Meakins. J. Chem. , 2601 (1965). 47. , B. Mayer, and B. Hemmens. Angew. Chem. Int. Ed. , 38, 3714 (1999). 48a. Ischia, M. , 37, 5773 (1996). REFERENCES 27 48b. Kelly, D. , S. Jones, J. O. Adogun, K. S. V. Koh, D. E. Hibbs, M. B. Hurdthous, and S.

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