The Bone Biopsy by Jenifer Jowsey (auth.)

By Jenifer Jowsey (auth.)

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Between ages 15 and 85 there has been a twofold decrease in bone mass within the periosteal boundary of the cortex including the marrow cavity and trabecular bone. amount lost per unit time is slower than in cortical bone (Table 2). Figures 22 and 23a and b illustrate this point. In the rib, which is composed mainly of cortical bone, the volume of mineralized bone inside the periosteal boundary decreases from approximately 56 to 26% over an age span of 70 years, a twofold decrease or a loss of about half the bone (Figure 22).

Possibily those reports exist in the Russian literature since Smimov is from the USSR. Fomasier (Fomasier and Vilaghy, 1973) uses a 3 mm diameter needle also, but without the asset of the split cylinder described by Smimov. Nevertheless, only 12% of the biopsies 68 CHAPTER 4 showed collapse or fragmentation of the trabeculae. Both demineralized sections stained with hematoxylin and eosin and with Masson's trichrome stain and also undemineralized, methacrylate embedded techniques were used on different blocks; a Jung microtome was used to cut 8 /Lm thick sections which were examined, stained or unstained.

Biopsies of the iliac crest are generally transilial and taken below the iliac crest, however, some investigators take biopsies vertically through the iliac crest (Figure 26). There is also variation in the type of bone used as well as in the method of preparing the sections. Probably the size of THE BONE BIOPSY 65 FIGURE 25. Microradiograph of a cross section of a rib of a normal adult human being. The majority of the bone is cortical and consists of secondary Haversian systems (magnification x 7).

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