Severe Asthma: Pathogenesis and Clinical Management (Lung by Stanley J Szefler, Donald Y. M. Leung

By Stanley J Szefler, Donald Y. M. Leung

Offering finished assurance of the pathophysiology, pharmacology, and administration of bronchial asthma from a multidisciplinary point of view, this completely revised and up-to-date reference stories the newest breakthroughs in antiinflammatory cures, natural drugs, airway home improvement, and disorder prevention techniques.

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12 Weiss have been found by Bodner. These data strongly support the suggestion that, in young adults, smoking is strongly associated with a diagnosis of asthma (20). In the late 1980s, Burrows reported that women with relatively little smoking history were likely to develop severe COPD (21). He noted that this fixed airflow obstruction was often associated with airways responsiveness and elevated IgE and positive skin prick tests, suggesting that fixed airflow obstruction seen in these women was a function of the asthma diathesis interacting with cigarette smoking exposure.

Phenotypes (asthma and atopy) as well as intermediate traits (BHR and total IgE levels) (26–31). However, the results of the genome-wide screens for asthma susceptibility genes reflect the genetic and environmental heterogeneity seen in asthma, in that while some regions have shown linkage in several studies, most show linkage in only one or two studies, even when these are undertaken in similar population groups. This illustrates the difficulty of identifying susceptibility genes for complex genetic diseases.

Risk Stratification of Subjects with Asthma X. Summary References 23. Management of Severe Asthma Antonio M. Vignola, Pascal Chanez, and Jean Bousquet I. II. III. IV. V. VI. Introduction Reasons for Asthma Treatment Failure Therapeutic Options for Severe Asthma Churg–Strauss Syndrome Management of Patients with Severe Asthma Conclusions References 24. Steroid-Resistant Asthma: New Insights and Implications for Management Donald Y. M. Leung, Joseph D. Spahn, and Stanley J. Szefler I. II. III. IV.

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