Rheumatology and Immunology Therapy
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Garland, New York 2. Cancer WEB’s On-line Medical Dictionary Graft rejection Allopurinol Trade Names Zyloprim. A 46 Allopurinol, in gout Class and Category Mechanism of Action Hypouricemic drugs. Allopurinol produces pseudoirreversible inactivation of xanthine oxidase-dehydrogenase, and is a substrate for this enzyme. Its major metabolite is oxypurinol, which effectively inhibits the enzyme. Inhibition of this enzyme reduces the synthesis of uric acid. Indications Hyperuricemia and gout; gout complications; prevention of tumor lysis syndrome; treatment of Chagas disease.
Allopurinol produces pseudoirreversible inactivation of xanthine oxidase-dehydrogenase, and is a substrate for this enzyme. Its major metabolite is oxypurinol, which effectively inhibits the enzyme. Inhibition of this enzyme reduces the synthesis of uric acid. Indications Hyperuricemia and gout; gout complications; prevention of tumor lysis syndrome; treatment of Chagas disease. Dosage Between 100 and 800 mg/day for gout and hyperuricemia. The administration of allopurinol is followed within 24 hours by a decrease in levels of serum and urinary uric acid.
Osteoporosis, calcium Indications Osteoporosis prevention and treatment in men, women, and among glucocorticoid users; Paget’s disease. 1. Black DM, Cummings CR, et al (1996) Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet 348:1535–41 2. Liberman UA, Weiss SR, Bröll J, et al (1995) Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. New Engl J Med 333:1437–43 Dosage ALG 3 Osteoporosis treatment: 70 mg weekly, 10 mg daily.