Rheumatoid Arthritis by Marc C. Hochberg MD MPH MACP, Alan J. Silman MD, Josef S.

By Marc C. Hochberg MD MPH MACP, Alan J. Silman MD, Josef S. Smolen MD FRCP, Michael E. Weinblatt MD, Michael H. Weisman MD

First Prize, Orthopaedics and Rheumatology, BMA Awards 2009 This state of the art reference offers present insights into the etiology, prognosis and administration of rheumatoid arthritis. prime foreign professionals in RA research the entire most up-to-date medical and scientific advancements in figuring out and dealing with this tough sickness, together with new strategies in pathogenesis, epidemiology, danger components, imaging, scientific results and therapy. it is the information you want to provide optimum care for your sufferers with rheumatoid arthritis. offers the paintings of prime overseas specialists in rheumatoid arthritis for suggestions you could belief. presents the very newest figuring out of the pathogenesis of rheumatoid arthritis, together with molecular pathways/mechanisms, and genetic and environmental components that instigate and force the disease.Includes finished insurance of scientific positive factors of rheumatoid arthritis together with articular, peri-articular and extra-articular manifestations, comorbidities, and final result measures-disease task, joint evaluate, imaging, and more-for specialist prognosis and tracking of disorder progression.Examines evidence-based therapy options-including conventional and biologic DMARDs and mixture therapies-as good as promising treatments at the horizon, putting updated information on affliction editing or illness controlling brokers at your fingertips.

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48. Helmick CG, Felson DT, Lawrence RC, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part I. Arthritis Rheum 2008;58(1):15–25. 49. Saraux A, Guedes C, Allain J, et al. Prevalence of rheumatoid arthritis and spondyloarthropathy in Brittany, France. J Rheumatol 1999; 26(12):2622–2627. 22 50. Andrianakos A, Trontzas P, Christoyannis F, et al. Prevalence and management of rheumatoid arthritis in the general population of Greece—the ESORDIG study.

Clin Rheumatol 2005;24(3):212–214. 42. Kvien TK, Glennas A, Knudsrod OG, et al. The prevalence and severity of rheumatoid arthritis in Oslo—Results from a county register and a population survey. Scand J Rheumatol 1997;26(6): 412–428. 43. Marotto D, Nieddu ME, Cossu A, Carcassi A. ]. Reumatismo 2005;57(4):273–276. 44. Akar S, Birlik M, Gurler O, et al. The prevalence of rheumatoid arthritis in an urban population of Izmir-Turkey. Clin Exp Rheumatol 2004;22(4):416–420. 45. Carmona L, Villaverde V, Hernandez-Garcia C, et al.

We have to carefully separate different subsets of RA in studies and descriptions of how environmental factors interact with genes in providing the basis for the onset of—and disease course for—different forms of RA. Having provided this general comment on the complexity as well as promise for studies on environmental factors and RA, the rest of this chapter will be devoted to description of what has hitherto been learned concerning the role of environment in this disease. Notably, however, almost all such studies have been conducted without dividing RA into subsets, and most studies on environment have not taken the genetics into account.

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