Progress in Systemic Lupus Erythematosus Research by Thomas I. Seward

By Thomas I. Seward

This new e-book is dedicated to modern learn advancements in lupus that is a of persistent irritation because of an autoimmune sickness. Autoimmune illnesses are health problems that ensue whilst the body's tissues are attacked via its personal immune approach. The immune procedure is a fancy method in the physique that's designed to struggle infectious brokers, for instance, micro organism, and different overseas invaders. one of many mechanisms that the immune approach makes use of to struggle infections is the construction of antibodies. sufferers with lupus produce irregular antibodies of their blood that concentrate on tissues inside of their very own physique instead of overseas infectious brokers. as the antibodies and accompanying cells of irritation can contain tissues anyplace within the physique, lupus has the capability to impact a number of components of the body.Sometimes lupus could cause illness of the outside, center, lungs, kidneys, joints, and/or apprehensive procedure. while merely the surface is concerned, the situation is termed discoid lupus. whilst inner organs are concerned, the is termed systemic lupus erythematosus (SLE).

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Gamez-Nava and Arnulfo Nava with SLE compared with matched controls. New methods such as electron-beam computed tomography have demonstrated a highly prevalence of coronary disorder even in asymptomatic patients. Additionally, high resolution carotid ultrasonography has shown a high prevalence of carotid lesions. Both cellular and molecular mechanisms of the accelerated atherosclerosis are complex and not entirely explained by the traditional cardiovascular risk factors, therefore, the research targets on nontraditional factors.

Cardiac dysfunction is another important area for research; several studies have shown a high prevalence of left ventricular diastolic dysfunction. In our own series this manifestation is present in around 63%. Nevertheless, to date no follow-up studies have been done to evaluate the importance of diastolic dysfunction on the morbidity or mortality. In summary cardiovascular disease in systemic lupus represents a very exciting area for research being necessary to increase the number of long-term prospective cohorts and well-designed controlled trials in order to improve the clinical care of the patients with this involvement.

New Frontiers in the Research of Cardiovascular Disease… 37 ATHEROSCLEROSIS IN SLE Most of the patients with SLE who have deceased by cardiovascular disease had an accelerated atherosclerosis. Atherosclerosis can be considered a chronic inflammatory condition on the vessel wall characterized by lipids (cholesteryl esters mainly) accumulated within the macrophages (foam cells) and smooth muscle cells in the intimal layer [15]. The lesions progress into atherosclerotic plaques composed by extracellular matrix component smooth muscle cells, macrophages, connective tissues, lymphocytes and a fibrous cap over a pool of extracellular lipid [15].

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