Pharmacology and therapeutics of cough by K. Fan Chung, John Widdicombe

By K. Fan Chung, John Widdicombe

The final decade has visible awesome advances in our wisdom of cough. this is applicable specifically to its simple mechanisms: the kinds of airway sensors, the pharmacological receptors on their membranes, the brainstem association of the ‘cough centre’, and the involvement of the cerebral cortex within the sensations and the voluntary keep watch over of cough. This publication indicates that easy stories are pointing to many most likely priceless techniques to the remedy of cough, in response to figuring out the fundamental peripheral receptor mechanisms, the brainstem pathways within the keep an eye on of cough, and the sensitization tactics that can practice in disease.

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Widdicombe’s studies in anesthetized cats (Widdicombe 1954a, 1954c) and our studies in anesthetized guinea pigs (Canning et al. 2004) concluded that the afferent nerves that regulate cough were myelinated (on the basis of axonal conduction velocities or sensitivity to vagal cooling). It has not been established whether the axons of cat cough receptors are also relatively slowly conducting (approximately 5 m s−1 ), as in guinea pigs. It is also unclear whether the cough receptors in cats are insensitive to smooth-muscle contraction, as are guinea pig cough receptors, in contrast to the intrapulmonary RARs in all species (see later).

6 Central Terminations and Pharmacology of Airway and Lung Afferent Nerves . . . . . 7 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 24 27 31 35 37 39 40 Abstract The afferent nerves regulating cough have been reasonably well defined.

1994; Pinto et al. 1995; Plevkova et al. 2004; Tatar et al. 1996, 1997; Trevisani et al. 2004; Xiang et al. 2002). These advantages and the careful electrophysiological analyses by Bergren (Bergren 1997, 2001; Bergren et al. 1984; Bergren and Kincaid 1984; Bergren and Myers 1984; Bergren and Sampson 1982), Fox (Fox et al. 1993, 1995), Joad (Bonham et al. 1995, 1996; Joad et al. 1997, 2004; Mutoh et al. 1999), Tsubone (Sano et al. 1992; Tsubone et al. 1991), Undem (Canning et al. 2004; Chuaychoo et al.

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