Pathologie des Thymus by Professor Dr. Herwart F. Otto (auth.)

By Professor Dr. Herwart F. Otto (auth.)

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35. , ~ , 19 lahre, Myasthenia gravis. 25 g schweres Thymektomiepriiparat). Anschnitte epithelialer Thymuszellen (EZ) mit Desmosomen (-+) und Intermediiirfilamenten (Fif). Lymphoblast (LyB). Fixierung nach Dalton. Kontrastierung: Bleizitrat und Uranylazetat. x 9000. (1. Nr. 193/73, Pathol. , Univ. Hamburg) lamenten findet man bis 5 nm durchmessende Mikrofilamente (Abb. 36) vom Actin-Typ 3 (DRENCKHAHN et al. 1979, LONING et al. 1981). Die Zellkerne der Thymus-Epithelzellen sind zumeist Uinglich-oval, gelegentlich tief gekerbt.

EBV ist ein B-Iymphotropes Virus. Mit verschiedenen Hybridisierungstechniken (WOLF 1981) ist es gelungen, virale DNA auch in (epithelialen) Zellen des (undifferenzierten) Nasopharynx-Karzinoms nachzuweisen. Auf welche Weise das vermutlich onkogene Virusmaterial in die epithelialen Tumorzellen, die keine EBV-Rezeptoren besitzen, gelangt [evtl. iiber Zellfusionen (WOLF et al. 1981)], ist nicht genau bekannt. Die virologischen (bzw. immunologischen) Aspekte der nasopharyngealen Karzinome sind 1981 anliiBlich der 65.

Nr. 339/77, Pathol. , Univ. Hamburg) ner", Processus superior thymi). Der kaudale Abschnitt des Organs (Basis) liegt mit seiner Dorsalfliiche dem Perikard auf. Jeder Thymuslappen hat etwa die Form einer "ventro-dorsal abgeplatteten Keule" [Einzelheiten der Thymustopographie: WIESEL (1912) und SOBOTTA (1914)]. Eine konstante Eigenform scheint nicht zu bestehen. Die Vielfalt der Thymusformen erkliirt sich nach W AHEED (1936) und BARGMANN (1943) "aus dem wechselnden Verhalten der Nachbarorgane und dem AusmafJe norma/er oder krankhafter Umbauvorgange im Thymus selbst" (vgl.

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