Occupational Asthma by Torben Sigsgaard, Dick Heederik

By Torben Sigsgaard, Dick Heederik

Fresh advancements in occupational bronchial asthma learn and scientific perform are the point of interest of this e-book. It discusses the contribution of occupational exposures to chemical and organic brokers to the load of bronchial asthma in adults, robust ways just like the use of apprentices reports, which come with younger contributors, na?ve with reference to occupational exposures, and diagnostic standards for paintings comparable and paintings irritated bronchial asthma. particular emphasis is given to publicity reaction relationships for allergen publicity, huge gene-environment reports and full genome screening ways. administration, prevention and surveillance are coated besides. Diagnostic principles are brought to rationalize the diagnostic workup and enhance the price advantage of surveillance schemes. matters within the layout of inhabitants stories are mentioned to aid the readers in designing and accomplishing their very own examine. This finished quantity provides new advancements altering the occupational bronchial asthma box within the coming years.

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Extra resources for Occupational Asthma

Sample text

Protective effects of house dust endotoxin on the development of atopy and asthma have been shown in children [67–69], and more recently, studies among adults have shown similar inverse relationships between endotoxin exposure and atopic asthma [8], allergic sensitization [65, 70, 71], and hay fever [64]. Thus, the more recent studies among occupationally exposed populations have shown that, in accordance with the hygiene hypothesis, effects of early exposures can be long-lasting. However, some of these studies also suggest that immune deviation from Th2 to Th1 responses may take place throughout life, and exposure in adulthood to endotoxin and other microbial compounds seem been associated with a lower prevalence of allergy or allergic asthma.

As a result, registries may give only crude estimates of the occurrence of disease, but at the same time allow evaluation of trends over time. Workforce-based studies have given most information about determinants of work-related asthma and allergy. An important determinant of asthma and allergy is the exposure intensity and for high-molecular-weight sensitizers atopy clearly modifies the risk. It is expected that improved phenotypical characterization of occupational asthma together with genotyping and detailed exposure assessment will give more insight in the occurrence and determinants of disease and prognosis.

Unfortunately, few examples can be found of application in epidemiological studies, and the response rate for repeated PEF testing in population surveys is usually low [10]. Incidence data from monitoring systems Considerable attention has been given to disease monitoring systems for asthma across the world since the mid-1990s when it became apparent that OA had replaced the pneumoconiosis as the leading occupational disease. A major source of information included disease registries for compensation purposes, since these also give an impression of the burden on society of OA.

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