New Therapeutic Targets in Rheumatoid Arthritis (Progress in by Paul-Peter Tak

By Paul-Peter Tak

This quantity makes a speciality of healing objectives that have been pointed out after TNF blockade. these types of ambitions have lately been registered or are presently less than improvement for the remedy of rheumatoid arthritis. each one bankruptcy explores the organic intent of a special healing aim in nice aspect. Readers will realize the most recent in vitro paintings, animal types, and effects from medical trials.

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These efforts have included lymphatic duct drainage, total lymphoid irradiation, inhibition of T cell trafficking and T cell depletion with antibodies targeting T lymphocyte surface markers. While some of these therapies initially showed promising results, none turned out to be clinically effective and all have been hampered New Therapeutic Targets in Rheumatoid Arthritis, edited by Paul-Peter Tak © 2009 Birkhäuser Verlag Basel/Switzerland 27 Eric M. Ruderman and Richard M. Pope by the toxicity associated with nonspecific T cell depletion.

Juvenile inflammatory arthritis Two additional controlled trials of abatacept, both recently published, are worth noting. In a trial of abatacept for juvenile inflammatory arthritis, 122 of 190 subjects met criteria for improvement after 4 months of open-label therapy with abatacept and were randomized to receive blinded therapy with abatacept or placebo for an additional 6 months [37] (Tab. 1). During the blinded portion of the trial, 53% of the placebo-treated patients flared, compared with just 20% of those treated 37 Eric M.

Ann Oncol 9: 995–1001 Igarashi T, Kobayashi Y, Ogura M, Kinoshita T, Ohtsu T, Sasaki Y, Morishima Y, Murate T, Kasai M, Uike N et al (2002) Factors affecting toxicity, response and progression-free survival in relapsed patients with indolent B-cell lymphoma and mantle cell lymphoma treated with rituximab: A Japanese phase II study. Ann Oncol 13: 928–943 Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, Feng P, Soppet D, Charters M, Gentz R, Parmelee D et al (1999) BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator.

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