Microfluidic Very Large Scale Integration (VLSI): Modeling, by Paul Pop, Wajid Hassan Minhass, Jan Madsen

By Paul Pop, Wajid Hassan Minhass, Jan Madsen

This e-book provides the state of the art strategies for the modeling, simulation, trying out, compilation and actual synthesis of mVLSI biochips. The authors describe a top-down modeling and synthesis method for the mVLSI biochips, encouraged via microelectronics VLSI methodologies. They introduce a modeling framework for the elements and the biochip structure, and a high-level microfluidic protocol language. assurance incorporates a topology graph-based version for the biochip structure, and a sequencing graph to version for biochemical program, exhibiting how the applying version should be acquired from the protocol language. The innovations defined facilitate programmability and automation, allowing builders within the rising, huge biochip market.

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Additional info for Microfluidic Very Large Scale Integration (VLSI): Modeling, Simulation, Testing, Compilation and Physical Synthesis

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Micromech. Microeng. 17(7), S122–S127 (2007) 20. : Lab-on-a-chip: a component view. J. Microsyst. Technol. 16(12) (2010) 21. : An efficient bi-criteria flow channel routing algorithm for flow-based microfluidic biochips. In: Proceedings of the Design Automation Conference, pp. 1–6. ACM (2014) 22. : Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. Chem. Soc. Rev. 39, 1153–1182 (2010) 23. : Simulated annealing-based placement for microfluidic large scale integration (mLSI) chips.

The pressure is turned on and off via off-chip, expensive, and bulky solenoid valves, which are in turn controlled by a computer. The number of controls is limited. For example, an mVLSI biochip control system from Microfluidics Innovation, LLC, has 36 control pins, interfaced to the biochip through a manifold. Although recent research has proposed top-down physical synthesis methods and tools, and programming languages and compilation techniques to automatically derive the control signals for the valve actuations (see Sect.

The flow path set is also generated in this step. , Heater 1 to Mixer 2 in Fig. 3b. , for the flow path Heater 1 to Mixer 2 in Fig. 3b, the source-sink path is (In4 , S10 , Heater 1 , S11 , S5 , Mixer 2 , S6 , Out2 ). Routing constraints are also extracted at this stage. , F7 and F2 in Fig. , S5 ) in their source-sink paths. Placement and routing. , placement of components and routing of flow channels while following the design rules. In this step, the allocated components are placed on a chip layout area and the interconnections between components are routed as channels on the chip such that the application completion time is minimized.

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