Lung Stem Cells in the Epithelium and Vasculature by Amy Firth, Jason X.-J. Yuan

By Amy Firth, Jason X.-J. Yuan

This e-book covers the id and position of endogenous lung stem cells in healthiness and ailment, quite the latest advances. furthermore, it discusses the quickly turning out to be box of stem cells and phone treatment because it pertains to lung biology and disorder in addition to ex vivo lung bioengineering. Such ways could provide novel healing ways for lung illnesses. Human pluripotent stem cellphone differentiation to version the pulmonary epithelium and vasculature can also be discussed.

World-recognized scientists who specialise in learning either the lung epithelium and pulmonary vasculature give a contribution the chapters. subject matters coated contain: stem telephone niches within the lung, the position of progenitor cells in fibrosis and bronchial asthma, iPSC in modeling lung sickness, vascular fix via endothelial progenitor cells and circulating fibrocytes in pulmonary vascular home improvement. This quantity of the Stem phone Biology and Regenerative Medicine sequence is key analyzing for researchers and clinicians attracted to stem cells, lung biology and regenerative drugs. it's also a useful source for complicated scholars learning mobilephone biology, regenerative drugs and lung physiology.

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2008) 18 Y. Liu 2 Type II Cells as Progenitors in Alveolar Repair 19 Excessive inflammation is a factor common to most of these models and plays an important role in causing cellular damage (Matute-Bello et al. 2011). 1 is a model of diphtheria toxin-induced lung injury (Barkauskas et al. 2013). Using a knock-in mouse in which the expression of diphtheria toxin in type II cells is induced following tamoxifen injection, there does not appear to be a clear inflammatory response (Barkauskas et al.

2013; Buckley et al. 2011). In injuries induced by hyperoxia, the generation of oxidants may also signal the initiation of the repair process (Pogach et al. 2007). Type II cells, in response to unknown signals related to specific injuries, can start proliferation and a type I cell transition, and they may also migrate to the injured region and engage in repair. Little is known regarding the molecules that regulate the type II cell activation that leads to alveolar repair. One would expect that the transcriptional programs involved in embryonic lung development, such as those under the control of the FGF and Wnt pathways (Cardoso 2001; Morrisey and Hogan 2010; Warburton et al.

Respir Res 2(1):33–46 Fehrenbach H, Kasper M, Tschernig T, Pan T, Schuh D, Shannon JM, Muller M, Mason RJ (1999) Keratinocyte growth factor-induced hyperplasia of rat alveolar type II cells in vivo is resolved by differentiation into type I cells and by apoptosis. Eur Respir J 14(3):534–544 Fehrenbach A, Bube C, Hohlfeld JM, Stevens P, Tschernig T, Hoymann HG, Krug N, Fehrenbach H (2003) Surfactant homeostasis is maintained in vivo during keratinocyte growth factor-induced rat lung type II cell hyperplasia.

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