Lung Injury: Mechanisms, Pathophysiology, and Therapy by Robert H. Notter, Jacob Finkelstein, Bruce Holm
By Robert H. Notter, Jacob Finkelstein, Bruce Holm
Progressing from basic medical rules and ideas to in-depth topical discussions of present study and remedy equipment, this finished reference defines the mobile and molecular mechanisms contributing to inflammatory lung damage and service. vast assurance is supplied on key mediators and pathways very important in acute and persistent pulmonary irritation and lung damage, in addition to the mechanistic pathophysiology of similar illnesses starting from medical acute lung damage (ALI) and the extreme respiration misery syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and different subacute and protracted stipulations. extra chapters additionally handle vascular disorder, surfactant disorder, reactive oxygen/nitrogen species, and mobile and animal versions of acute and persistent lung harm.
Read Online or Download Lung Injury: Mechanisms, Pathophysiology, and Therapy PDF
Best pulmonary & thoracic medicine books
This new e-book offers an obtainable overview of the sector of lung biology and ailment aimed toward the graduate or scientific scholar and biomedical researcher. The ebook starts off through contemplating the anatomy and ultrastructure of the lung and the tracheal and bronchial approach, the regulate of respiratory in addition to the basics of pulmonary body structure, gasoline trade and circulate.
Meant for busy practitioners, Pulmonary Pathology is a pithy, pocket-sized consultant to the entire key pulmonology entities and diagnoses that pulmonologists see in day-by-day perform. It addresses non-neoplastic stipulations together with Infections, Granulomatous ailments, Acute Lung damage, Idiopathic Interstitial Pneumonias, Vasculitis, Histiocytoses, Lung Pathology in Systemic illnesses, Transplant-Related Lung Pathology, and Miscellaneous Non-Neoplastic stipulations.
With a wide quantity of ultrasound photographs and instructing movies, Pleural Ultrasound for Clinicians: A textual content and booklet is a print and interactive electronic source that gives functional tips for all these project pleural ultrasound investigations and methods. With transparent, unique directions for scientific perform, it's going to aid clinicians: realize general anatomy in addition to universal pleural pathologies ideal ideas for ultrasound-guided pleural methods tips on how to opt for the proper ultrasound apparatus for his or her division try out their wisdom during the self-assessment and revision sections
Acute breathing misery Syndrome (ARDS) continues to be a massive explanation for morbidity and mortality all over the world, and the prevalence is expected to extend with the getting older inhabitants a number of scientific issues can begin ARDS, together with pneumonia, sepsis, gastric aspiration and trauma yet regardless of severe learn during the last forty years, we nonetheless have an incomplete knowing of the pathophysiology of the ailment and therapy is still principally supportive.
- Textbook of Lung Cancer, Second Edition
- Diagnosis and Treatment of Pulmonary Hypertension: From Bench to Bedside
- Benumof and Hagberg's Airway Management
- Pharmaceutical Inhalation Aerosol Technology, Second Edition, (Drugs and the Pharmaceutical Sciences)
- Therapeutic Strategies in Asthma: Modern Therapeutic Targets
- Proteoglycans in Lung Disease (Lung Biology in Health and Disease)
Extra resources for Lung Injury: Mechanisms, Pathophysiology, and Therapy
The incidence of ALI/ARDS has been variably reported to be 50,000–150,000 cases per year in the United States, with high associated mortality and morbidity (1,14,17,21–26). A recent analysis by Goss et al. (27) has estimated that the actual incidence of clinical ALI in the United States is even higher at 22–64 cases per 100,000 persons per year. In addition to involving severe acute respiratory failure, ALI/ARDS can also progress to a “fibroproliferative” phase of disease that involves chronic lung injury with tissue remodeling and the initiation of fibrosis (15,18–20).
Ideally, the repair processes should mimic ontogeny since the use of different processes for repair than those used in normal morphogenesis would require a greater repertoire of genetic regulatory programs. In order to understand repair processes within the lungs, it is essential first to understand the physiology of normal lung development, including that of the early lung. This chapter summarizes current thoughts about lung development, growth, and repair. * The early stage of development of a complex organism is called the embryo; the following stage persisting through birth is called the fetus.
80. Charafeddine L, D’Angio CT, Richards JL, Stripp BR, Finkelstein JN, Orlowski CC, LoMonaco MB, Paxhia A, Ryan RM. Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung. Am J Physiol 1999; 20:L105–L113. 2 Principles of Lung Development, Growth, and Repair IAN COPLAND, KEITH TANSWELL, and MARTIN POST Departments of Pediatrics, Physiology, and Laboratory Medicine and Pathology, Lung Biology Research Programme, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada I.