Lung Injury: Mechanisms, Pathophysiology, and Therapy by Robert H. Notter, Jacob Finkelstein, Bruce Holm

By Robert H. Notter, Jacob Finkelstein, Bruce Holm

Progressing from basic medical rules and ideas to in-depth topical discussions of present study and remedy equipment, this finished reference defines the mobile and molecular mechanisms contributing to inflammatory lung damage and service. vast assurance is supplied on key mediators and pathways very important in acute and persistent pulmonary irritation and lung damage, in addition to the mechanistic pathophysiology of similar illnesses starting from medical acute lung damage (ALI) and the extreme respiration misery syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and different subacute and protracted stipulations. extra chapters additionally handle vascular disorder, surfactant disorder, reactive oxygen/nitrogen species, and mobile and animal versions of acute and persistent lung harm.

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Extra resources for Lung Injury: Mechanisms, Pathophysiology, and Therapy

Sample text

The incidence of ALI/ARDS has been variably reported to be 50,000–150,000 cases per year in the United States, with high associated mortality and morbidity (1,14,17,21–26). A recent analysis by Goss et al. (27) has estimated that the actual incidence of clinical ALI in the United States is even higher at 22–64 cases per 100,000 persons per year. In addition to involving severe acute respiratory failure, ALI/ARDS can also progress to a “fibroproliferative” phase of disease that involves chronic lung injury with tissue remodeling and the initiation of fibrosis (15,18–20).

Ideally, the repair processes should mimic ontogeny since the use of different processes for repair than those used in normal morphogenesis would require a greater repertoire of genetic regulatory programs. In order to understand repair processes within the lungs, it is essential first to understand the physiology of normal lung development, including that of the early lung. This chapter summarizes current thoughts about lung development, growth, and repair. * The early stage of development of a complex organism is called the embryo; the following stage persisting through birth is called the fetus.

80. Charafeddine L, D’Angio CT, Richards JL, Stripp BR, Finkelstein JN, Orlowski CC, LoMonaco MB, Paxhia A, Ryan RM. Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung. Am J Physiol 1999; 20:L105–L113. 2 Principles of Lung Development, Growth, and Repair IAN COPLAND, KEITH TANSWELL, and MARTIN POST Departments of Pediatrics, Physiology, and Laboratory Medicine and Pathology, Lung Biology Research Programme, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada I.

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