Lung growth and development by John Alexander McDonald

By John Alexander McDonald

Displays the explosion of data and technological breakthroughs that experience facilitated investigations into the improvement of the lung-including recombinant DNA know-how, molecular genetics, transgenics, and advances in lung mobilephone and mo-lecular biology. presents approximately 2800 bibliographic citations and over one hundred seventy tables, drawings, and x-rays to assist make clear particular discussions.

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Zone I to zone II boundary is the site of formation, growth, and differentiation of gas exchange region. The future conductive airways are lying in zone III (III), which is characterized by epithelial tubes with an outer layer of smooth muscle cell precursors (smc). Light micrograph × 150. Page 6 segments in samples of three human lungs and calculated that more than 20 and 22 generations of air spaces were present in the pseudoglandular and canalicular stages, respectively. For comparison, the adult human lung contains on average 24 generations of airways inclusive of the trachea (15).

At the cranial end of the outpouching, a connection of the lung to the foregut is maintained, corresponding to the later hypopharynx with its entrance to the larynx. The lung bud elongates, soon divides dichotomously, and invades the surrounding mesenchyme. 5 weeks, the lung anlage shows five tiny saccules, two on the left-hand side and three on the right-hand side, thus preforming the future lobar bronchi and the corresponding lung lobes. By successive dichotomous divisions, the complexity of what corresponds to the future airway tree increases rapidly.

Regulation of Compensatory Lung Growth634 IV. Role of Soluble Factors in Compensatory Lung Growth639 V. Current Status of the Field650 VI. Conclusions652 References652Author Index661Subject Index729 Page xix LUNG GROWTH AND DEVELOPMENT Page 1 1 Structural Aspects of Prenatal and Postnatal Development and Growth of the Lung PETER H. BURRI University of Berne Berne, Switzerland I. Introduction A. Overview The development of the human lung encompasses a period starting with the first appearance of the tracheal bud in the developing embryo and ending somewhere in early childhood.

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