Lessons in Ornamental Penmanship by Zaner, C P

By Zaner, C P

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The likelihood that the existing PTS components are involved in a regulatory network independent of transport function will b investigated. It is anticipated that the results of this study will improve understanding of the growth requirements, oxygen utilization, and regulatory systems of T. pallidum. ; Associate Professor; University of Washington Seattle, Wa 98195 Timing: Fiscal Year 2001 Summary: Syphilis is a major public health problem in parts of the US and in the developing world. A vaccine to prevent syphilis is urgently needed.

P. pallidum Nichols strain will lead to protection against challenge with Nichols strain. Immunization using the variable and constant domains will be compared, as will immunization with multiple versus single msp homologues. 2. p. pallidum The RFLPs of the4 variable domains of msp- homologue genes are different from strain to strain. In this aim, the variable domains of different strains will be compared by sequence analysis. 3. p. pallidum. We hypothesize that strain heterogeneity of msp-homologues explain the lack of cross-protection after infection with heterologous strains.

We hypothesize that functional activities such as attachment, invasion, etc. The long-term goal of our studies is to develop a better understanding of variation of the subgroup 3 tpr genes and their corresponding proteins. The specific aims for the project are: (1) To detect nucleotide sequence variations within or flanking the tprJ, tprE, and tprG genes of T. pallidum obtained a various timepoints from chances of intradermally infected rabbits; (2) To examine expression of the TprJ, TprE and TprG proteins in T.

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