Immunology at a glance by J. H. L. Playfair

By J. H. L. Playfair

Immunology at a Glance presents a simple assessment of the body’s defence mechanisms. excellent from day considered one of a scientific, biomedical or existence technological know-how path, the textual content starts with a easy evaluation of either adaptive and innate immunity, sooner than progressing to utilized immunological strategies, which examine what occurs whilst issues get it wrong, and the way, in medical drugs, every one physique approach might be stricken by immunity.

Each double-page unfold corresponds to a customary lecture and diagrammatically summarises center ideas in immunology, via obtainable schematic diagrams on left-hand pages, with key issues concisely summarised at the right-hand web page. There also are self-assessment essay questions so that you can try your knowledge.

New for this tenth edition:

  • Thoroughly up to date and reorganised chapters provide larger readability and more uncomplicated realizing for these new to the subject
  • New chapters on cytokine receptors and ‘Immunology within the Laboratory’
  • A thoroughly re-written part on autoimmunity
  • A fresh significant other site that includes self-assessment questions and PowerPoint slides of pictures from the ebook, perfect for educating and revision at

Immunology at a Glance is the precise spouse for an individual approximately to begin a brand new path in immunology and should entice clinical and biomedical technology scholars. ideal for examination instruction, it offers the thoughts and frameworks you must achieve your exam.

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Sample text

24), deficiencies of which can cause profound defects in lymphocyte development. Cortex Dark-staining outer part packed with lymphocytes, compartmentalized by elongated epithelial cells. The process of proliferation and selection occurs mainly here. Medulla Inner, predominantly epithelial part, to which cortical lymphocytes migrate before export via venules and lymphatics. The final stages of selection may occur at the cortico-medullary junction. PCV Post-capillary venule, through which lymphocytes enter the thymic veins and ultimately the blood.

One of the most exciting developments in biology was the discovery that it is possible to perpetuate individual lymphocytes by fusing them with a tumour cell. In the case of B lymphocytes, this can mean an endless supply of individual, or monoclonal, antibodies, which has had far-reaching applications in the diagnosis and treatment of disease and the study of cell surfaces. Indeed, the classification of lymphocytes themselves, and of most other cells too, is now mainly based on patterns of reactivity with a large range of monoclonal typing antibodies (see Appendix III).

CD45 This transmembrane protein was originally known as ‘leucocyte common antigen’ because it is found on all white blood cells. However, on T cells it distinguishes ‘memory’ T cells (those that have already encountered antigen) from ‘naive’ T cells (those that have yet to encounter antigens). The extracellular portion of CD45 exists in a number of variant forms. The shortest form (known as CD45Ro) is found on activated and memory T cells, but not on most naive T cells (see Fig. 15). In contrast, one of the longer forms (CD45RA) is found predominantly on naive T cells.

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