IgE and Anti-IgE Therapy in Asthma and Allergic Disease by Robert Fick

By Robert Fick

Exploring the function of Immunoglobulin-E (IgE) in human affliction, this reference summarizes present examine at the mechanisms and usage of anti-IgE therapeutics within the therapy of IgE-mediated allergic ailment, irritation, and asthma-discussing the structural composition of excessive- and low-affinity IgE receptors, the airway cells that categorical those receptors, and the useful job of IgE-FceRI and IgE-FceRII interactions for more desirable regulate and administration of allergic disorders.

Compiles formerly unpublished facts from the 1st large clinical investigations of Xolair!

IgE and Anti-IgE treatment in bronchial asthma and Allergic Disease

  • reviews stories at the distribution of serum IgE degrees of ordinary and asthmatic populations in constructed areas of the area equivalent to the U.S., Canada, Scandinavia, New Zealand, and Europe
  • offers novel equipment for the layout and formula of monoclonal antibodies
  • discusses using allergen bronchoprovocation to spot the features and efficacy of latest antiasthma and antiallergy drugs
  • examines the position of IgE in nutrients and parasitic allergies
    and covers
  • the pathogenesis of atopic dermatitis and urticaria
  • novel techniques to focus on mast cells and basophils
  • murine versions of allergic pulmonary irritation
  • the pathophysiology of allergic rhinitis
    Supplemented with approximately 2000 modern references to facilitate additional research, IgE and Anti-IgE treatment in bronchial asthma and Allergic affliction is an in-depth and well timed resource for simple and scientific immunologists; allergists; pulmonologists and pulmonary disorder experts; physiologists; molecular, mobile, and lung biologists; pediatricians; internists; and graduate and scientific tuition scholars in those disciplines.
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    Extra info for IgE and Anti-IgE Therapy in Asthma and Allergic Disease

    Example text

    V. 17. Role of IgE and Food Allergens Ricki M. Helm and A. Wesley Burks I. II. III. IV. V. VI. VII. VIII. IX. X. XI. XII. 18. Introduction Atopic Dermatitis Urticaria and Angioedema Other Autoimmune Diseases with Skin Involvement Conclusions References Introduction Characterization of Food Allergens Pathophysiology of IgE-Mediated Food Allergy Major Foods/Allergens Involved with IgE-Mediated Disease Diagnosis of Food Allergy Cross-Sensitivity Between Foods Prevention Control Treatment Genetically Engineered Crop Plants Epidemiology/Case Studies Summary References Role of IgE in Allergic Bronchopulmonary Aspergillosis Priscilla S.

    The crystal structure also shows that binding of one FcεRIα to one IgE prevents binding of a second FcεRIα, as previously determined in binding experiments. II. Nonanaphylactogenic Anti-IgE Antibody Identification and Humanization Early studies on anti-IgE antibodies using mouse IgE and rat FcεRI-expressing RBL cells and FcεRII expressing B cells focused on elucidating their binding epitopes by competition and cross blocking studies and relating these epitopes to those segments of IgE involved in binding to FcεRI and FcεRII (58–63).

    In: Samter M, Alexander HL, eds. Immunological Diseases. London: J & A Churchill, 1965:519–538. 5. Ishizaka K, Ishizaka T. Identification of γE-antibodies as a carrier of reaginic activity. J Immunol 1967; 99:1187. 6. Johansson SGO, Bennich H. Studies on a new class of human immunoglobulins. I. Immunological properties. In: Killander J, ed. Gammaglobulins. Structure and Control of Biosynthesis. Stockholm: Almqvist & Wiksell, 1967:193–197. 7. Johansson SGO. Raised levels of a new immunoglobulin class (IgND) in asthma.

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