Gene Therapy in Inflammatory Diseases by Christopher H. Evans, Paul D. Robbins

By Christopher H. Evans, Paul D. Robbins

Gene remedy for inflammatory illnesses is a brand new , burgeoning box of medication. Edited via the undisputed pioneers of this quarter of analysis, this quantity is the 1st dedicated to its subject. It includes 13 chapters, every one written by way of leaders of their respective fields, that summarize the state-of-the-art in constructing novel, gene established remedies for inflammatory ailments. in addition to delivering an creation to the elemental recommendations of gene remedy and using bare DNA methods, the booklet describes the advances which have been made in employing them to arthritis, lupus, a number of sclerosis, diabetes, Sjogren`s syndrome and transplantation.One bankruptcy is dedicated to discussing the 1st human scientific trials that practice gene treatment to the therapy of an inflammatory sickness. in addition to offering novel healing methods, gene remedy allows the advance of latest and superior animal types of affliction; a bankruptcy describing those advances can also be incorporated. As an up to date, well timed ebook written by way of th

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To imitate the situation in a rheumatoid joint we, therefore, established a novel scm mouse model in which human RA synovium was co-implanted with normal human cartilage under the renal capsule of SCID mice [37]. This experimental approach provided us with important insights into the molecular and cellular events leading to destruction of human cartilage by RA synovium. Both RA synovial tissue and normal human cartilage could be successfully implanted into SCID mice for more than 300 days without alteration of their characteristic biological features.

Annu Rev Immunol12: 141-179 Verma 1M, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S (1995) RelfNFkappa BII kappa B family: intimate tales of association and dissociation. Genes Dev 9: 2723-2735 Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol14: 649-83: 649-683 Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (1997) IkappaB kinase-beta: NFkappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278: 866-869 Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, et al (1997) IKK-l and IKK-2: cytokine-activated IkappaB kinases essential for NF- kappaB activation.

Arthritis Rheum 39: 1410-1418 Gene therapy for rheumatoid arthritis: preclinical studies 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 Baeuerle PA, Baichwal VR (1997) NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv Immunol65: 111-137 Baichwal VR, Baeuerle PA (1997) Activate NF-kappa B or die? Curr Bioi 7: R94-6 Miagkov AV, Kovalenko DV, Brown CE, Didsbury JR, Cogswell JP, Stimpson SA, Baldwin AS, Makarov SS (1998) NF-KB activation provides the potential link between inflammation and hyperplasia in the arthritic joint.

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