Frontiers in Tissue Engineering by C.W. Patrick, A.G. Mikos, L.V. McIntire

By C.W. Patrick, A.G. Mikos, L.V. McIntire

Frontiers in Tissue Engineering is a gently edited compilation of cutting-edge contributions from a world authorship of specialists within the various topics that make up tissue engineering. A extensive illustration of the clinical, medical, business and regulatory group is unique within the ebook. The paintings is an authoritative and finished reference resource for scientists and clinicians operating during this rising box.

The publication is split into 3 components: basics and strategies of tissue engineering, tissue engineering utilized to specialized tissues, and tissue engineering utilized to organs. The textual content deals many novel ways, together with an in depth assurance of cell-tissue interactions at mobile and molecular degrees; cell-tissue floor, biochemical, and mechanical environments; biomaterials; engineering layout; tissue-organ functionality; new ways to tissue-organ regeneration and substitute of functionality; moral concerns of tissue engineering; and executive rules of tissue-engineered items.

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Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell, 1996, 84, 345-357. Cell-Extracellular Matrix Interactions 27 6. Hynes, R. , Integrins: a family of cell surface receptors. Cell, 1987, 48, 549-554. 7. Hynes, R. , Integrins: Versatility, modulation, and signaling in cell adhesion. Cell, 1992, 69, 11-25. 8. Albelda, S. M. and Buck, C. , Integrins and other cell adhesion molecules. FASAB Journal, 1990, 4, 2868-2880. 9. , Kornberg, L. , Signal transduction by cell adhesion receptors.

Cellular interactions are required to be highly specific in nature for proper regulation of events to result in homeostatic inflammation and coagulation. Inflammatory processes normally protect the body from infections by foreign pathogens. However, when dysregulated, leukocyte migration to healthy tissues can lead to unwanted disorders and pathologic conditions. Similarly, defective modulation of the hemostatic mechanism can lead to the formation of platelet rich thrombus which can compromise the patency of the blood Cell-Cell Interactions 29 vessel.

Cadherins Cadherins are transmembrane, calcium dependent family of glycoproteins mediating cell-cell interaction by binding homophilically with adjacent cells. This family of adhesion molecules is responsible for tissue morphogenesis as well as maintaining the integrity of solid tissues. Cadherins form the so called adherens junctions which not only strengthen cell-cell adhesion but also aids signal transfer between neighboring cells. Members of the cadherin superfamily are type I integral membrane proteins.

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