Etodolac - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications
By Icon Health Publications
It is a 3-in-1 reference publication. It offers a whole scientific dictionary overlaying countless numbers of phrases and expressions when it comes to etodolac. It additionally provides broad lists of bibliographic citations. ultimately, it offers info to clients on the best way to replace their wisdom utilizing quite a few net assets. The publication is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to familiarize yourself with examine devoted to etodolac. in case your time is efficacious, this booklet is for you. First, you won't waste time looking out the web whereas lacking loads of appropriate details. moment, the ebook additionally saves you time indexing and defining entries. eventually, you won't waste money and time printing 1000s of web content.
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Additional info for Etodolac - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Tablets and capsules. The Physicians' Desk Reference, 49 Edition, 1995, at page 2682, teaches that etodolac is insoluble in water but soluble in alcohols, chloroform, dimethyl sulfoxide and aqueous polyethylene glycol. pn=US05958445__ • Process for preparing 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)-indole-1-acetic acid, etodolac Inventor(s): Demerson; Christopher A. (Plainsboro, NJ), Humber; Leslie G. (North Brunswick, NJ) Assignee(s): American Home Products Corporation (New York, NY) Patent Number: 4,585,877 Date filed: May 6, 1985 Abstract: A process for preparing 1,8-diethyl-1,3,4,9-tetrahydro[3,4-b]-indole-1-acetic acid (etodolac) is disclosed.
Pat. No. Patents 43 4,012,417 by the reaction of 7-ethyltryptophol and the keto ester, ethyl propionylacetate, followed by alkaline hydrolysis. The 7-ethyltryptophol is produced by the reaction of 2ethylphenylhydrazine with 4-hydroxybutyraldehyde. A. A. degree. C. degree. C. 5 and 5. Excerpt(s): The present invention regards a process for the preparation of etodolac. The need is felt for having available an alternative process for the preparation of etodolac which does not involve the drawbacks presented by the processes of the known art.
Also disclosed are methods for treating the above-described conditions in a human while substantially reducing the adverse effects that are associated with the racemic mixture of etodolac, by administering the R-isomer of etodolac to said human. The active compound of the present compositions and methods is an optical isomer of the compound etodolac, also known as etodolic acid, which is described in Humber, L. G. , J. Med. Chem. 29: 871-874 (1986); Humber, L. G. S. Pat. No. 3,843,681 and German Patent No.