Energy-Linked Functions of Mitochondria. Papers Presented at by Dr. Britton Chance

By Dr. Britton Chance

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Additional resources for Energy-Linked Functions of Mitochondria. Papers Presented at the First Colloquium of the Johnson Research Foundation of the University of Pennsylvania, Philadelphia, April 13, 1963

Example text

2. Action of oligomycin on respiratory control associa­ ted with the terminal phosphorylation site of the mitochond­ rial respiratory chain. Conditions as in Fig. 1. showing loss of respiratory control. Release of the inhib­ ition was brought about by 50 μΜ DNP, in agreement with the action of uncoupling agents of this type at other oligomycininhibited phosphorylation sites in the respiratory chain. 6 μg/ml also abolish the phosphorylating respiration in the terminal part of the chain, but longer periods of incubation are required as the concentration of oligomycin is decreased.

1; 50 per cent inhibition is obtained at inordinately high levels just as in the siiccinate-linked DPN reduction system. It would appear that, at least in these particles, the classical antimycin site operating between cytochromes b and c^^, is not involved in DPN reduction by succinate or ascorbate and menadione. On the basis of these results, the pathway of electron flow in Reaction 1 may be represented as in Fig. 2· The hydroqui- none produced by non-enzymatic reduction by ascorbate may reduce either cytochrome b or CoQ or the DPNH dehydrogenase flavoprotein.

The relationship between these activities and the coupling function remains to be clarified. I might point out that although the apparent purification of Peaks I and II appears 31 ENERGY-LINKED FUNCTIONS OF MITOCHONDRIA TABLE II PYTQPbgßphfltag? agi^j-yj^T oí. 28 to be only 5-folcl, the actual purification is probably con­ siderably higher since the crude extract would show the indi­ vidual activities of the two peaks as well as the added stim­ ulation when both are present as indicated in Table II.

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