Diabetic Retinopathy - A Medical Dictionary, Bibliography, by Icon Health Publications

By Icon Health Publications

In March 2001, the nationwide Institutes of well-being issued the next caution: "The variety of websites delivering health-related assets grows on a daily basis. Many websites offer worthy details, whereas others can have details that's unreliable or misleading." moreover, a result of speedy raise in Internet-based info, many hours may be wasted looking out, deciding on, and printing.This booklet was once created for doctors, scholars, and contributors of most people who are looking to behavior scientific study utilizing the main complex instruments on hand and spending the smallest amount of time doing so.

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In our preliminary studies, we demonstrate that haPHC 1) is highly expressed in placenta and heart and localized to the Golgi apparatus and endoplasmic reticulum; 2) hydrolyzes NBD-Clz-phytoceramide preferentially in vitro, and 3) is activated by Ca2+,but inhibited by sphingosine (6). These results support the hypothesis that haPHC has very restricted substrate specificity; its action is regulated by second messengers; and its expression is compartment and tissue specific. To test this hypothesis, we will purify haPHC and determine its substrate specificity using different phytoceramide analogs, effects of cations and lipids on its activity, its cellular localization, and tissue specific expression.

We anticipate that this study will provide preliminary evidence to establish a link between dysregulation of MMP activity and the pathogenesis of nephropathy in type 1 DM. ; Ophthalmology; University of Pennsylvania 3451 Walnut Street Philadelphia, Pa 19104 Timing: Fiscal Year 2002; Project Start 01-APR-2001; Project End 31-MAR-2006 Summary: (Applicant's Abstract) The main objective of this proposal is to provide Dr. Tolentino a mechanism for rigorous training both technically and conceptually in gene therapy and molecular biology.

Methodological advances will be incorporated into a computer package to be made available on the World Wide Web. Our second objective is to carry out power and sample size calculations for several different longitudinal ophthalmologic study designs, under various assumptions about the prevalence of bi-ocular versus uni-ocular disease, differential treatment allocation, loss-to-follow-up, and expected adherence to study treatment(s). , aspirin) on sample size, frequency of evaluation, and power will be considered.

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