Copper and the Skin by Jurij J. Hostynek, Howard I. Maibach
By Jurij J. Hostynek, Howard I. Maibach
Copper is more and more well-known for its attainable function within the prevention and moderation of sickness, in addition to the therapy of a few stipulations together with dermis inflammation, sensitization, rheumatoid arthritis, and different inflammatory stipulations. This resource experiences common ideas of percutaneous penetration to explain the mechanisms controlling anti inflammatory task, dermal sensitivity, and the absorption of copper compounds within the human physique and the consequences of those services on fit pores and skin and human future health.
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Extra resources for Copper and the Skin
49. Walker WR, Beveridge SJ, Whitehouse MW. Antiinﬂammatory activity of a dermally applied copper salicylate preparation (Alcusal). Agents Actions 1980; 10:1–10. 50. Beveridge SJ, Whitehouse MW, Walker WR. Lipophilic copper(II) formulations: some correlations between their composition and anti-inﬂammatory/ anti-arthritic activity when applied to the skin of rats. Agents Actions 1982; 12: 225–231. 51. Odintsova NA. Permeability of human skin to potassium and copper ions and their ultrastructural localization.
By that method, the systemic uptake of permeants can be derived from the amount that diffuses into the SC in vivo after a limited time of exposure (35). The chemical is dosed on the skin of animals or human volunteers, and after 30-minute-contact the surface of Basics of Metal Skin Penetration: Scope and Limitations 29 the SC wiped clean of residual compound, and the SC removed by successive application of adhesive tape and stripping. The strippings are analyzed for chemical adhering to tissue removed, and from that value the amount may be estimated that eventually will be systemically absorbed over a longer period of time.
Certain metal compounds (organometallics) also represent a lipophilic category (36) that can penetrate the SC with relative ease. Such derivatives of the more toxic heavy metals, therefore, represent a major toxicological risk, particularly in the work place, due to their ready skin penetration. 3 Â 10À3 cm/hr for lead naphthenate51. Electrolytes In our present understanding of structure and function of the skin, its permeation is determined by the physicochemical parameters of permeants. Intuitively, and also based on the therapeutic action of dermatologicals and cosmeceuticals, or the toxic effect of skin exposure to pesticides, we anticipate easy penetration by lipophilic compounds there, as is achieved in the process of inunction.