Comprehensive Organic Synthesis: Combining C-C pi-Bonds by L.A. Paquette

By L.A. Paquette

The tenet underlying the subject material in particular compiled in quantity five has been to make to be had to the natural chemical neighborhood a sourcebook comprehensively overlaying the entire vital &pgr;-bond-dependent variations. Thermal, photochemical, and metal-catalyzed cycloadditions of each significant style are expertly specific by way of the main an expert researchers in those parts. The synthetically helpful electrocyclic and sigmatropic procedures the place alkenic facilities are in detail focused on the structural switch are equally canvassed in compact aspect. With additional cognizance given to ene reactions, small-ring rearrangements, and comparable transition metal-associated reactions, insurance has been accomplished of the whole diversity of natural adjustments at once concerning the rebonding of alkenic facilities. to that end, this quantity may still function the excellent sourcebook of the sphere for the following decade and past.

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The polymerization is carried out in a sealed container. After completion of the polymerization, the container is broken and the polymer monolith is coarsely crushed, then ground and sieved to obtain particles of appropriate size range. The template molecules are extracted from the polymer. Finally, the polymer particles are dried. This protocol is time- and labor-intensive and produces large amounts of particles of unwanted size fractions. 5). 5 Scanning electron micrograph of irregular MIP particles.

The rebinding, however, relies on noncovalent interactions. When the covalently bound template moiety is cleaved from the MIP, a functional group capable of interacting non-covalently with the target molecule is left behind in the polymer at the cleavage site. The semi-covalent approach has been used successfully for the preparation of MIPs selective for p-aminophenylalanine ethyl ester [69], phenol [70] and triazines [71] among others. The cavity left behind after cleaving off the covalently bound template moiety is often too small to accommodate the target molecule during non-covalent rebinding.

Meldal, M. and Bock, K. (1999) Journal of the American Chemical Society, 121, 5459–66. 44 Atherton, E. C. (1989) Solid Phase Peptide Synthesis: A Practical Approach, IRL Press, Oxford. 45 Kempe, M. and Barany, G. (1996) Journal of the American Chemical Society, 118, 7083–93. 46 Meldal, M. (1992) Tetrahedron Letters, 33, 3077–80. 47 Renil, M. and Meldal, M. (1996) Tetrahedron Letters, 37, 6185–8. 48 Buchardt, J. and Meldal, M. (1998) Tetrahedron Letters, 38, 8695–8. , Meldal, M. and Bock, K. (1999) Chemistry – A European Journal, 5, 1088–95.

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