Comparative Genetic Toxicology: The Second UKEMS by J.M. Parry, C.F. Arlett
By J.M. Parry, C.F. Arlett
This selection of sixty nine papers investigates 'in vitro' metabolic activation arrangements for 2 particular pairs of chemical analogues, benzidine (BZD) with 4,4-diaminoterphenyl (DAT) and 4-dimethyl-aminoazobenzene (DAB) with 4-cyanodimethylaniline (CDA). The arrangements chosen have been uninduced rat liver (using rats of a similar pressure because the bioassay). Aroclor-induced rat liver, uninduced mouse liver (using a similar mouse pressure as utilized in the 'in vivo' cytogenetics assays), and uninduced chook. the foremost bulk of the assays defined within the learn concerned using huge universal batches of those fifty nine arrangements. The research used to be subsidized through the uk Environmental Mutagen Society (UKEMS) and may stand as a major landmark in genetic toxicology.
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Additional resources for Comparative Genetic Toxicology: The Second UKEMS Collaborative Study
Progr. Mutat. Res. 1: 660-665 Von Brandt, J. and Hoehne, G. (1952). On the mutagenic activity of some carcinogenic, cytostatic and antibiotic agents. K. and Hashimoto, Y. (1981). Unscheduled DNA synthesis induced by 4-aminoazobenzene, N-hydroxy-4aminoazobenzene, and their derivatives in primary cultures of rat and mouse hepatocytes. M. (1978). Further improvements in the hepatocyte primary culture DNA repair test for carcinogens: detection of carcinogenic biphenyl derivatives. M. (1980). DNA repair and mutagenesis in liver cultures as indicators in chemical carcinogen screening.
1981). Induction of mitotic aneuploidy in the yeast strain D6 by 42 coded compounds. Progr. Mutat. Res. J. (1980). Transformation of Syrian hamster embryo cells by diverse chemicals and correlation with their reported carcinogenic and mutagenic activities. Chem. Mutagens: Prin. J. K. (1980). The use of Fischer rat embryo cells as a screen for chemical carcinogens and the role of the nontransforming type "C" RNA tumor viruses in the assay. Adv. Mod. Environ. Toxicol. S. E. (1980). Chemically-induced DNA repair synthesis in primary rat hepatocytes: a correlation with bacterial mutagenicity.
Chemicals Both BZD and DAT were supplied by UKEMS and were formulated as solutions in dimethylsulphoxide (DMSO) on the day of use. Bacterial mutation assay The method used was that described by Ames et al. (1975) incorporating 4%, 10% or 30% Aroclor-induced rat liver or non-induced All tests were carried out using chicken liver S9 in the S9 mix. three plates per data point. RESULTS AND DISCUSSION The results obtained with BZD are shown in figures 1 and 2. Bacterial Mutation (Core Study) 50 a 350l 4% 59 in the 59 mix 10% 59 in the 59 mix X 30% 59 in the 59 mix ~ 300 ~ ~ Q.