Bone Resorption by Felix Bronner, Mary C. Farach-Carson, Janet Rubin

By Felix Bronner, Mary C. Farach-Carson, Janet Rubin

This booklet displays the meteoric raise in wisdom relating to bone home improvement together with molecular realizing of osteoclast improvement, regulatory molecules comparable to cytokines, pathophysiology and pharmaceutical improvement to regard osteoclast functionality. fast ebook of an up to date quantity addressing those matters by way of specialists within the box, an asset to any library of scientific endocrinologists and rheumatologists, could be a priceless learn for these getting into the medical area of bone home improvement study. it's going to combine contemporary technological advances with origin information to supply a accomplished view of bone resorption, and also will hyperlink details received from the genetic and molecular to the physiological and scientific degrees This quantity is addressed to scientific practitioners, food scientists, researchers and scholars, who search a basic figuring out of this significant topic. a useful e-book for the neighborhood of scientific experts- internists, endocrinologists, nephrologists, orthopaedists- in addition to dental, paramedical, nursing and veterinary practitioners. precious additionally for these getting into the sector of bone biology, in addition to these at the research/clinical interface who locate it tough to discover a whole sequence to carry them ?up to hurry? with technological developments during this quarter.

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Roodman GD, Ibbotson KJ, MacDonald BR, Kuehl TJ, Mundy GR (1985) 1,25-Dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow. Proc Natl Acad Sci USA 82:8213–17. Rubin C, Gross T, Qin YX, Fritton S, Guilak F, McLeod K (1996) Differentiation of the bone-tissue remodeling response to axial and torsional loading in the turkey ulna. J Bone Joint Surg Am 78:1523–33. Rubin C, Lanyon L (1984) Regulation of bone formation by applied dynamic loads.

Thus, local factors present in the immediate vicinity of the bone seem to be important in stimulating cathepsin K activation. Early studies of the ability of cathepsin K to degrade bone proteins suggested that it was not very effective against collagen or fibronectin, but readily degraded osteonectin [9]. It has since been documented that optimal cathepsin K activity toward collagen requires a complex of the cathepsin molecule and soluble glycosaminoglycans [58]. Intriguingly, Hou et al. [58] have shown that cathepsin K cleaved aggrecan aggregates at two specific sites, thereby generating the soluble glycosaminoglycans required for formation of the active complex themselves.

2003) Expression and role of mannose receptor/terminal high-mannose type oligosaccharide on osteoclast precursors during osteoclast formation. J Endocrinol 176:285–92. 126. Motyckova G, Weilbaecher KN, Horstmann M, Rieman DJ, Fisher DZ, Fisher DE (2001) Linking osteopetrosis and pycnodysostosis: regulation of cathepsin K expression by the microphthalmia transcription factor family. Proc Natl Acad Sci USA 98:5798–803. 127. Nakamura I, Tanaka H, Rodan GA, Duong LT (1998) Echistatin inhibits the migration of murine prefusion osteoclasts and the formation of multinucleated osteoclast-like cells.

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