Behçet's Disease: From Genetics to Therapies by Yoshiaki Ishigatsubo

By Yoshiaki Ishigatsubo

This e-book, in addition to reviewing easy and medical facets of Behçet's illness, covers the most recent findings, together with genetic reports and remedy with biologics for the illness.
Although the reason for Behçet's illness remains to be unknown, it really is popular that genetic elements, equivalent to HLA-B51, are concerned about its improvement. lately, novel susceptibility loci together with IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 were pointed out, supplying new insights into the pathogenesis of the ailment. as well as uncomplicated study, the important efficacy of anti-TNF-alpha monoclonal antibodies has additionally been advised for not just uveitis linked to the affliction but additionally different subtypes of the sickness akin to entero-, vasculo-, and neuro- Behçet's illness. Behçet's affliction: From Genetics to Therapies offers crucial info either for uncomplicated researchers operating within the fields of immunology, irritation, and genetics, and for medical physicians who're drawn to Behçet's ailment, similar to ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.​

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The role of TLR2 and 4 in Behcet’s disease pathogenesis. Innate Immun. 2013;20(4):412–22. 1177/1753425913498042. Durrani O, Banahan K, Sheedy FJ, et al. TIRAP Ser180Leu polymorphism is associated with Behcet’s disease. Rheumatology (Oxford). 2011;50:1760–5. Yavuz S, Elbir Y, Tulunay A, Eksioglu-Demiralp E, Direskeneli H. Differential expression of toll-like receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet’s disease etiopathogenesis. Rheumatol Int. 2008;28:401–6.

Molecularphylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104:13780–5. Chapter 3 Genetics Akira Meguro and Nobuhisa Mizuki Abstract The etiology of Behçet’s disease (BD) is still unclear, but currently some external environmental factors are thought to trigger BD in individuals with a particular genetic background. It is well established that BD is strongly associated with the human leukocyte antigen (HLA) class I allele, HLA-B*51, in many different ethnic groups, indicating that the HLA-B*51 allele is one of the genetic factors underlying BD.

Shimizu J, Kaneko F, Suzuki N. Skewed helper T cell responses to IL12 family cytokines produced by antigen presenting cells and the genetic background in Behcet’s disease. Genet Res Int. 2013. 1155/2013/363859. 35. Kim ES, Kim SW, Moon CM, et al. Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet’s disease in Korean population. Life Sci. 2012;90:740–6. 36. Xavier JM, Shahram F, Davatchi F, et al. Association study of IL10 and IL23RIL12RB2 in Iranian patients with Behçet’s disease.

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