Asthma in the Workplace, Third Edition by David I. Bernstein, Moira Chan-Yeung, Jean-Luc Malo, I.

By David I. Bernstein, Moira Chan-Yeung, Jean-Luc Malo, I. Leonard Bernstein

Addressing each key element of occupational asthma-including illness mechanisms, medical prognosis, remedy, and different types of causative agents-this 3rd variation offers knowledgeable survey of the main influential advances and examine within the box. offering new and accelerated chapters on genetics, environmental tracking, pathophysiology, dermis and pulmonary interactions, and the surveillance and prevention of occupational bronchial asthma, this consultant will stand on my own because the most modern resource at the subject.

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Sample text

Jack Pepys can no longer personally witness the rapid evolution 24 Pepys and Bernstein of the discipline he helped to pioneer, but it would have been a great source of satisfaction to him that some of his predictions about the future of OA either have already transpired or are beginning to emerge in the relatively short period of time since the original publication of this book. This remarkable upsurge in OA and the ensuing medical interest it has engendered has culminated in two major occupational symposia [the first (93) and the second Jack Pepys Occupational Symposia, Montreal and Toronto, Canada, respectively] since publication of the second edition.

An important area of future research on the allergenic effects of reactive lowmolecular-weight chemicals is shown by the capacity of the platinum halide salts to create in affected subjects neoantigens in human serum albumin, against specific IgE antibody that is formed. This antibody can react with neoantigens in serum albumin resulting from combination with other unrelated chemical haptens. Thus in platinum salt-sensitive workers, 4 out of 38 gave positive RASTs to human serum albumin compared with 3 out of 116 nonsensitive subjects.

3), the concentration was increased gradually, one test per day, up to 40 mg/kg, which elicited reactions to the dust after carefully monitored exposures of 4 to 30 minutes. This elicited immediate, dual, and isolated late asthmatic reactions. Skin testing was approached with caution in view of severe reactions to scratch and intradermal tests (18,42,43). Skin prick tests starting with a 10À6 concentration up to 10À3 are effective for demonstrating sensitivity (44), and subsequently specific IgE antibodies were shown in the majority Historical Aspects of Occupational Asthma 17 Figure 4 Occupation-type test as in Figure 3 with mixture of 1 g of 6APA in 250 g lactose.

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