Asthma in the Workplace, Fourth Edition by Malo, Jean-Luc

By Malo, Jean-Luc

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Additional resources for Asthma in the Workplace, Fourth Edition

Example text

If so, this may also have contributed to the increasing rates of OA among work-related lung diseases in these societies. The classic approach to the study of occupational lung disease focuses on the environmental determinants with careful documentation of exposure levels by objective measurement. Objectives include characterizing the exposure–response relationships for the purposes of (i) establishing a causal relation between a contaminant and the respiratory effect under study, and/or (ii) providing the scientific basis for establishing workplace control levels.

Respiratory health surveillance in a toluene di-isocyanate production unit, 1967–97: 107. 108. 109. 110. clinical observations and lung function analyses. Occup Environ Med 2000; 57: 43–52. Tarlo SM, Liss GM, Yeung KS. Changes in rates and severity of compensation claims for asthma due to diisocyanates: a possible effect of medical surveillance measures. Occup Environ Med 2002; 59: 58–62. Saary MJ, Kanani A, Alghadeer H, Holness DL, Tarlo SM. Changes in rates of natural rubber latex sensitivity among dental school students and staff members after changes in latex gloves.

Second, several but not all studies (45,46) show poor correlation between responses to questions on asthma symptoms and the presence or absence of non-specific bronchial hyperresponsiveness (NSBH) originally regarded as the hallmark of asthma. Third, bronchial hyperresponsiveness can exist without symptoms (47). Fourth, some asymptomatic subjects with bronchial hyperresponsiveness can develop symptoms in subsequent years (47,48). Fifth, questionnaires administered by trained physicians have variable sensitivity and specificity in predicting asthma or OA (49–52).

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