Ankylosing spondylitis and Klebsiella by Alan Ebringer
By Alan Ebringer
Ankylosing spondylitis and Klebsiella is a accomplished and informative textual content at the reason behind Ankylosing spondylitis. Ankylosing spondylitis (AS) is a situation which impacts 20 million humans world wide and is probably going brought on or initiated by way of a bowel an infection from Klebsiella bacteria.
When a sufferer is contaminated by way of Klebsiella bacteria, his or her immune approach will make antibodies opposed to the entire antigens or molecules present in the microbe. simply because the various bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but additionally the self tissues equivalent to the joints and the cells having a similar HLA molecules, that is how the affliction AS begins. this is often the concept that of molecular similarity or “molecular mimicry” which formerly has been came upon to paintings in different autoimmune ailments; rheumatic fever and rheumatoid arthritis.
The first paper in this topic used to be released in 1976 and because thenover a hundred papers on rheumatological subject matters were released, from Prof Ebringer’s workforce, on the department of lifestyles Sciences, King’s collage in London, united kingdom.
The appropriate details from those papers is extracted and awarded during this publication layout making it available to overall healthiness execs, study associations, pharmaceutical businesses and universities and most people.
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Extra resources for Ankylosing spondylitis and Klebsiella
In haemagglutination studies, the rabbit HLA-B27 lymphocyte antisera raised with Freund’s complete adjuvant have been shown to agglutinate, up to a titre of 1/512, sheep and rabbit red cells coated with Klebsiella extracts prepared by several different methods. Other rabbit antisera, also raised with Freund’s complete adjuvant against a variety of protein antigens, viruses and microorganisms including Salmonella typhimurium and Escherichia coli, did not exceed a haemagglutination titre of 1/16 when tested with Klebsiella LPS-coated sheep red blood cells.
Julkunen H, Pyorala K, Lehtaurirta F. Hyperostosis of the spine in relation to age and hyperglycaemia in men aged 30–60. Ann Med Intern Fenn. 1968;57:1–7. Léri A. Études sur les affections de la colonne vertébrale. Paris: Masson; 1926. Rogers J, Watt I, Dieppe P. Paleopathology of spinal osteophytosis, vertebral ankylosis, ankylosing spondylitis and vertebral hyperostosis. Ann Rheum Dis. 1985;44:113–20. Schilder DP, Harvey WP, Hufnagel CA. Rheumatoid spondylitis and and aortic insuffciency. N Engl J Med.
Each point is a mean (± standard error) of estimations with six different typing sera. 05 1/55 dilution Fig. 2 Competition assay between HLA typing sera and rabbit anti-Klebsiella serum for 125 I-Klebsiella sonicate preparation. Histograms indicate mean (± standard error) of sera tested, and each serum estimation was done in quadruplicate 42 5 Molecular Mimicry Between HLA-B27 and Klebsiella Bacteria These investigations were started after the demonstration of an association between HLA-B27 and ankylosing spondylitis patients (Caffrey and James 1973).