Advances in pulmonary drug delivery by Philip Chi Lip Kwok, Hak-Kim Chan

By Philip Chi Lip Kwok, Hak-Kim Chan

The breathing tract has been used to convey biologically lively chemical compounds into the human physique for hundreds of years. even though, the lungs are complicated of their anatomy and body structure, which poses demanding situations to drug supply. Inhaled formulations are often extra subtle than these for oral and parenteral management. Pulmonary drug improvement is as a result a hugely really good zone as a result of its many specified concerns and demanding situations. fast development is being made and provides novel strategies to latest remedy difficulties. Advances in Pulmonary Drug Delivery highlights the most recent advancements during this field.

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1 Schematic illustrates steps involved in the delivery of siRNA into the lungs� (Reproduced from Lam, J�K�-W� et al�, Adv. Drug Deliv.

Patton and Samantha R. 1 Examples of siRNA-Based Therapeutics in Clinical Trials for Lung Diseases Product Name ALN-RSV01 Excellair™ Delivery Agent/ Route of Administration Naked siRNA/ intranasal Unknown/inhalation Latest Development Status Indication Sponsor RSV infection Alnylam pharmaceuticals Zabecor pharmaceuticals Asthma IIb (completed) II BARRIERS TO siRNA DELIVERY TO THE LUNG As illustrated in Figure 3�1, there are generally five steps that siRNA go through when administered via pulmonary route� Although local delivery of siRNA could obviate the need for targeting and the interaction with serum nuclease to minimize degradation, the lung itself possesses some intrinsic anatomic, physiologic, immunologic, and metabolic hurdles for efficient siRNA delivery� The specific barriers to lung 1.

Patton and Samantha R. 1 Examples of siRNA-Based Therapeutics in Clinical Trials for Lung Diseases Product Name ALN-RSV01 Excellair™ Delivery Agent/ Route of Administration Naked siRNA/ intranasal Unknown/inhalation Latest Development Status Indication Sponsor RSV infection Alnylam pharmaceuticals Zabecor pharmaceuticals Asthma IIb (completed) II BARRIERS TO siRNA DELIVERY TO THE LUNG As illustrated in Figure 3�1, there are generally five steps that siRNA go through when administered via pulmonary route� Although local delivery of siRNA could obviate the need for targeting and the interaction with serum nuclease to minimize degradation, the lung itself possesses some intrinsic anatomic, physiologic, immunologic, and metabolic hurdles for efficient siRNA delivery� The specific barriers to lung 1.

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