Advances in combination therapy for asthma and COPD by Jan Lotvall

By Jan Lotvall

content material: Similarities and changes within the pathophysiology of bronchial asthma and COPD / Christian Virchow --
Glucocorticoids : pharmacology and mechanisms / Peter Barnes --
Inhaled corticosteroids? medical results in bronchial asthma and COPD / Paul O'Byrne --
LABAS : pharmacology, mechanisms and interplay with anti inflammatory remedies / Gary Anderson --
lengthy and ultra-long performing beta-2-agonists / Mario Cazzola --
the protection of long-acting beta agonists and the advance of blend remedies for bronchial asthma and persistent obstructive pulmonary illness / Eugene Bleecker --
Inhaled blend remedy with glucocorticoids and long-acting beta-2-agonists in bronchial asthma and COPD, present and destiny views / Jan Lotvall --
Novel anti inflammatory remedies for bronchial asthma and COPD / Ian Adcock --
Novel biologicals by myself and together in bronchial asthma and hypersensitive reaction / William Busse --
Anti-infective remedies in bronchial asthma and COPD / Jonathan D.R. Macintyre & Sebastian L. Johnston --
lengthy performing muscarinic antagonists in bronchial asthma and COPD / Denis O'Donnell --
Phosphodiesterase inhibitors in obstructive lung disorder / Jan Lotvall --
organic cures in improvement for COPD / Riccardo Polosa --
Triple therapy?, within the administration of persistent obstructive lung illness (COPD). the worth of mix remedy with inhaled steroid, lengthy appearing anticholinergicbronchodilator and lengthy performing beta 2 agonist bronchodilator in COPD / Ronald Dahl.

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Effect of dexamethasone on interleukin-1␤-IL-1␤)induced nuclear factor-kB (NF-kB) and kB-dependent transcription in epithelial cells. Eur J Biochem 1998;254:81–9. 24. Mittelstadt PR, Ashwell JD. Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. J Biol Chem 2001;276:29603–10. 25. Lasa M, Abraham SM, Boucheron C, Saklatvala J, Clark AR. Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.

Glucocorticoid inhibition of GMCSF from T cells is independent of control by NF-␬B and CLE0. Am J Respir Cell Mol Biol 2004;30:555–63. 39. Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 2006;27:413–26. 40. Barnes PJ. Cortoicosteroid effects on cell signalling. Eur Respir J 2006;27(2):413–26. 41. Clark AR. MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids? J Endocrinol 2003;178:5–12. 42. Engelbrecht Y, de Wet H, Horsch K, Langeveldt CR, Hough FS, Hulley PA.

Glucocorticoid receptor homodimers bind to GRE sites in the promoter region of glucocorticoid-responsive genes. Interaction of the activated glucocorticoid receptor dimer with GRE usually increases transcription. Glucocorticoid receptors may increase transcription by interacting with coactivator molecules, such as CBP, thus activating histone acetylation and gene transcription. 4). 4 Glucocorticoid activation of anti-inflammatory gene expression. Glucocorticoids bind to cytoplasmic glucocorticoid receptors (GR), which translocate to the nucleus where they bind to glucocorticoid response elements (GRE) in the promoter region of steroid-sensitive genes and also directly or indirectly to coactivator molecules such as CREB-binding protein (CBP).

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