Acquired Neuromuscular Disorders: Pathogenesis, Diagnosis by Corrado Angelini

By Corrado Angelini

This e-book presents cutting-edge details at the pathogenesis, analysis, and therapy of more than a few inflammatory, autoimmune, and idiopathic neuromuscular issues. the hole part discusses the differential prognosis of got myopathies according to scientific, electrophysiological, muscle biopsy, and serological standards, with distinctive specialize in the position of electromyography and antibody trying out. all the correct scientific entities is then mentioned intimately, the insurance together with, for instance, myasthenia gravis, polymyositis, immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic neuropathies, and diabetic polyneuropathy. transparent information is supplied on at present on hand remedies, with descriptions of the newest advances in physiotherapy, drug remedy, and respiration care. different beneficial properties of this clinically orientated ebook are the inclusion of many illustrative case displays and contributions by way of overseas authors from prime centers.

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Extra resources for Acquired Neuromuscular Disorders: Pathogenesis, Diagnosis and Treatment

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Berger M, McCallus DE, Lin CS-Y (2013) Rapid and reversible responses to IVIG in autoimmune neuromuscular diseases suggest mechanisms of action involving competition with functionally important autoantibodies. J Peripher Nerv Syst 296:275–296 60. Miura Y, Devaux JJ, Fukami Y et al (2015) Contactin 1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia. Brain 138(Pt 6):1–8 61. Kawamura N, Yamasaki R, Yonekawa T et al (2013) Anti-neurofascin antibody in patients with combined central and peripheral demyelination.

1). Adipose infiltration and edema, defined as increased extracellular and/or intracellular water, are the main structural changes detectable by T1- and T2-weighted MRI sequences. Adipose intramuscular replacement is detectable by T1-weighted sequences (Fig. 2) in which fat has a high signal because of its short relaxation time, differently from muscle tissue [8, 9]. T2-weighted images may be used in detecting both intramuscular edema and fat infiltration (Fig. 3). Both water and fat have longer T2 relaxation times than healthy muscle, thus explaining the brightness of muscle tissue on T2 sequences when it is affected by either these conditions [8, 9].

Manganelli not completely known in human diseases, but it probably relates on Na and Cl channel abnormalities. In fact, a reduced conductance for chloride can reduce the leak of this ion in the transverse tubular extracellular space after the depolarization with a consequent relative increase of extracellular potassium concentration (K ions are released with chloride ions). This K concentration could raise until a level which determines depolarization of transverse tubular membrane with repetitive responses to a single presynaptic impulse.

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